Lymphoma discovery made by local labs
By Cai Wenjun |
April 17, 2013, Wednesday
|
Print Edition
Print Edition
RESEARCHERS at the Shanghai Medical College of Fudan University announced that they have discovered a major "switch'' that may regulate lymphoma, potentially leading to earlier diagnosis and new drugs.
Lymphoma is a cancer that begins in white blood cells. They move through the body's lymphatic system.
Lymphoma is difficult to detect, develops quickly and has a high mortality rate. About 90 percent of patients are in the terminal stage when the cancer is found. The five-year survival rate is below 2 percent.
The discovery was published in yesterday's editions of Cancer Cell.
The key is an enzyme that produces lactate that normally supplements the body's energy.
When the enzyme level rises, a large amount of lactate is produced and flows out of cells to create an ideal environment for a tumor to grow, experts said.
Fudan researchers spent three years studying enzyme level changes. They found a protein modification that is a "switch" for the enzyme.
"This discovery can be developed into effective diagnostic reagents for early stages of lymphoma and even targeted drugs to treat lymphoma," said Lei Qunying, the leading researcher.
Lymphoma is a cancer that begins in white blood cells. They move through the body's lymphatic system.
Lymphoma is difficult to detect, develops quickly and has a high mortality rate. About 90 percent of patients are in the terminal stage when the cancer is found. The five-year survival rate is below 2 percent.
The discovery was published in yesterday's editions of Cancer Cell.
The key is an enzyme that produces lactate that normally supplements the body's energy.
When the enzyme level rises, a large amount of lactate is produced and flows out of cells to create an ideal environment for a tumor to grow, experts said.
Fudan researchers spent three years studying enzyme level changes. They found a protein modification that is a "switch" for the enzyme.
"This discovery can be developed into effective diagnostic reagents for early stages of lymphoma and even targeted drugs to treat lymphoma," said Lei Qunying, the leading researcher.
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