Gene found for heart formation
Print Edition
Chinese scientists identified a gene critical for the development of the network of nerves wrapped around the heart and its surrounding vasculature, according to a recently published study.
The discovery can potentially improve the prevention and treatment of diseases like coronary artery disease, a leading global cause of mortality, said the study that was published in the US journal Science Signaling.
Zhang Zhen from Shanghai Children鈥檚 Medical Center and his colleagues pinpointed the gene 鈥淲dpcp鈥 as an important player in coronary plexus formation in mice.
This gene is known for its role in the formation of cell cilia, or eyelash-like structures that help control locomotion. The coronary arteries and the nerves surrounding them are essential for providing oxygen and nutrition to the heart muscle.
Their development involves two major steps: the cells from the heart鈥檚 inner lining form the primitive coronary plexus, which then begins the remodeling process by recruiting cells from outside of the heart.
The remodeling stage is essential for smooth muscle cells, the building blocks of artery walls, to surround the vessels in the primitive coronary plexus. Studying mice with mutated Wdpcp, the researchers found that although the primitive coronary plexus formed properly and quickly, the remodeling stage was defective because of impaired migration of cells from the outside the heart.
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