Research may help Alzheimer鈥檚 diagnosis
CHINESE scientists have conducted a whole-genome sequencing study for Alzheimer’s disease in China’s population for the first time and have identified two new genetic risk factors associated with Alzheimer’s.
A team of researchers led by Shenzhen Institute of Advanced Technology have identified common variants in GCH1 and KCNJ15 that show suggestive associations with Alzheimer’s.
The research was published in the journal “Proceedings of the National Academy of Sciences.”
Alzheimer’s is an age-related neurodegenerative disease and the pathogenesis of the disease is not fully clear. Pathophysiological mechanisms are complex, with genetic factors playing critical roles. Previous genome-wide association studies have identified several risk loci and genes associated with Alzheimer’s.
Most existing genetic data on Alzheimer’s, however, is from Caucasian populations, and information for other ethnic populations is limited.
China has more than 7 million Alzheimer’s patients and the number is expected to rise with the aging population. As susceptibility to certain genetic risk factors varies among populations, it is necessary to report a whole-genome sequencing study for Alzheimer’s in the Chinese population, according to SIAT.
The team selected a group of Chinese Alzheimer’s patients and a group of healthy Chinese people of the same age and conducted genotype-expression analysis to further investigate the underlying biological mechanism.
Besides the two new genetic risk factors, the research also show that the risk genes interact with human immune signals, revealing the relationship between the immune system dysfunction and Alzheimer’s.
The research may help in early diagnosis of Alzheimer’s, biomarker research and drug development.
- About Us
- |
- Terms of Use
- |
-
RSS
- |
- Privacy Policy
- |
- Contact Us
- |
- Shanghai Call Center: 962288
- |
- Tip-off hotline: 52920043
- 娌狪CP璇侊細娌狪CP澶05050403鍙-1
- |
- 浜掕仈缃戞柊闂讳俊鎭湇鍔¤鍙瘉锛31120180004
- |
- 缃戠粶瑙嗗惉璁稿彲璇侊細0909346
- |
- 骞挎挱鐢佃鑺傜洰鍒朵綔璁稿彲璇侊細娌瓧绗354鍙
- |
- 澧炲肩數淇′笟鍔$粡钀ヨ鍙瘉锛氭勃B2-20120012
Copyright 漏 1999- Shanghai Daily. All rights reserved.Preferably viewed with Internet Explorer 8 or newer browsers.