Drug discovered that kills breast cancer stem cells
Source: Agencies |
August 15, 2009, Saturday
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AMERICAN researchers have discovered a compound that can kill breast cancer stem cells, a kind of master cancer cell that resists conventional treatment and may explain why many cancers grow back, they reported on Thursday.
The discovery came using a new method of screening for drugs that specifically target and kill cancer stem cells, and it could be used to find drugs targeting other cancer stem cells as well, they said.
Many teams have been looking for ways to destroy these master cancer cells in hopes of making cancer easier to cure.
"There is a lot of evidence to suggest now that these cells are responsible for many of the recurrences that are observed after treatment has stopped," said Piyush Gupta of the Massachusetts Institute of Technology and the Broad Institute, whose study appears in the journal Cell.
The problem is that cancer stem cells are rare and difficult to study in the lab because they quickly change into other types of cells. And they are hard to kill.
"It wasn't clear it would be possible to find compounds that selectively kill cancer stem cells," Gupta said in a statement. "That's what we did."
To study the cells, Gupta's team first devised a method for stabilizing cancer stem cells in the lab and getting them to multiply. They then tested them against 16,000 natural and commercial chemical compounds to see which ones were able to kill the cancer stem cells specifically.
A chemical called salinomycin hit the target. Gupta said it is not clear if salinomycin will emerge as the best drug compound for killing breast cancer stem cells -- or that it will be safe to use in people with cancer. But the study offers a new approach for drug companies to isolate and test compounds capable of killing the cells.
The discovery came using a new method of screening for drugs that specifically target and kill cancer stem cells, and it could be used to find drugs targeting other cancer stem cells as well, they said.
Many teams have been looking for ways to destroy these master cancer cells in hopes of making cancer easier to cure.
"There is a lot of evidence to suggest now that these cells are responsible for many of the recurrences that are observed after treatment has stopped," said Piyush Gupta of the Massachusetts Institute of Technology and the Broad Institute, whose study appears in the journal Cell.
The problem is that cancer stem cells are rare and difficult to study in the lab because they quickly change into other types of cells. And they are hard to kill.
"It wasn't clear it would be possible to find compounds that selectively kill cancer stem cells," Gupta said in a statement. "That's what we did."
To study the cells, Gupta's team first devised a method for stabilizing cancer stem cells in the lab and getting them to multiply. They then tested them against 16,000 natural and commercial chemical compounds to see which ones were able to kill the cancer stem cells specifically.
A chemical called salinomycin hit the target. Gupta said it is not clear if salinomycin will emerge as the best drug compound for killing breast cancer stem cells -- or that it will be safe to use in people with cancer. But the study offers a new approach for drug companies to isolate and test compounds capable of killing the cells.
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