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November 9, 2019

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MSD’s ‘Inventing for Life’ resonates with visitors

THIRTY years ago, pharmaceutical company MSD made a decision that may have changed the lives of millions of people in China: it agreed to conduct technology transfer of hepatitis B vaccine to China — possibly the country that needed it most at that time.

To commemorate this milestone decision, MSD China held a celebration at the ongoing China International Import Expo, and promised to continue its journey of facilitating China’s public health.

“Public health is beyond borders, and this technology transfer 30 years ago may be one of the best decisions for the 20th century,” said Joseph Romanelli, senior vice president of MSD and president of MSD in China.

In the 1980s, hepatitis B was a serious disease threatening Chinese people’s health. At the same time, MSD had developed then the world’s most advanced recombinant DNA hepatitis B vaccine and launched it in the United States in 1986.

In order to solve hepatitis B infection, MSD decided to transfer hepatitis B vaccine technology to China in 1989 and to help instruct and train Chinese scientists and engineers.

“At the beginning, we hoped to sell hepatitis B vaccine to China. But even if its price was lowered to the minimum level, Chinese families might still not be able to afford it,” Roy Vagelos, former MSD CEO and chairman, wrote in his memoirs. “The situation was so urgent and I wanted to protect children from this deadly disease.”

In the final contract signed with the Chinese government, MSD promised neither to charge any patent fee or profit, nor sell hepatitis B vaccine produced by MSD on the Chinese mainland. Vagelos said: “MSD was trying to use this technology to solve a huge medical problem and help those who faced the risks of the diseases but could not afford it.”

Later, MSD helped establish hepatitis B vaccine production sites in Beijing and Shenzhen to ensure the quality of hepatitis B vaccine produced in China was no different to that in the US.

In 1993, China produced the first batch of recombinant hepatitis B vaccines and began to use them. In 2002, hepatitis B vaccine was included in the China National Immunization Program, thus more newborns have been protected from mother-to-child hepatitis B infection.

In May 2012, China received a certificate from the World Health Organization, saying it had achieved the goal of reducing the chronic hepatitis B infection rate among children under 5 to below 2 percent and had set a good example for other developing countries.

In 2014, the WHO praised the Chinese government in recognition of China’s outstanding achievements in the prevention and control of hepatitis B-related disease mainly due to the high vaccination rate among children and a 95 percent plus vaccination rate among newborns.

“It was an unforgettable journey and resonated the principle of MSD that we are here first to help people who need help,” said Romanelli.

MSD has been committed to developing innovative medicines and vaccines to build a “health Great Wall” for the general public.

At the CIIE, MSD displays its innovative products and R&D pipelines in oncology, vaccine, diabetes and anti-infection at its booth under the theme of “Inventing for Life.” 

“China’s deepening health care reform has provided new opportunities for MSD,” said Romanelli, adding that he had a firm belief that the process would gain further momentum.

“We can feel it here at the CIIE that China has committed even further in its opening-up process.”

In 2018, MSD had nine innovative drugs and vaccines approved in China — ranging from preventative vaccines to cancer immunotherapy drugs.


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