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May 5, 2014

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City team’s breakthrough in blood-clotting research

A BREAKTHROUGH by Shanghai scientists offers the possibility of improved drugs to treat cardiovascular disease and other blood-clotting conditions.

A team from the Shanghai Institute of Materia Medica, the Chinese Academy of Sciences, has decoded the structure of P2Y12R protein, which is responsible for the formation of blood-clotting protein.

Thrombus — or blood-clotting — includes conditions such as strokes and coronary heart disease. In China, 2 million people suffer strokes each year.

The global market for thrombus treatments is worth billions of US dollars in annual sales.

“A detailed three-dimensional structure is important to study the working mechanism from a molecular level and make more effective and less risky drugs,”  said Zhao Qiang, the program’s leading researcher.

The team’s findings are published in the journal “Nature.”


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