Clinical trials of 3 vaccines approved
Print Edition
CHINA has approved three COVID-19 vaccines for clinical trials, an official with the Ministry of Science and Technology said yesterday.
An adenovirus vector vaccine, developed by a research team led by Chen Wei, an academician with the Chinese Academy of Engineering and a researcher at the Institute of Military Medicine under the Academy of Military Sciences, was the first to be approved for clinical trials, said Wu Yuanbin, director-general of science and technology for social development with the ministry.
The first phase of the clinical trial was completed at the end of March, and the second phase started on April 12.
It is the first COVID-19 vaccine in the world that has entered the second phase of clinical trials, according to the World Health Organization.
Accompanied by his daughter, Xiong Zhengxing, an 84-year-old man in Wuhan, was vaccinated on April 13, becoming the oldest volunteer in the second phase of the clinical trial.
Compared with the first phase, the second phase has removed the age ceiling to enroll volunteers over 60. As the elderly make up a high percentage of the severely ill COVID-19 patients, the vaccine should build a safety shield for them, Chen said.
Taking the modified defective adenovirus as the vector, the vaccine carries the gene of the coronavirus spike protein, the major surface protein used by the virus to bind to a receptor to invade cells, so that the subject’s body will produce the immunological memory of the protein. When the real coronavirus attacks, the body will identify its spike protein and stop its invasion, according to Chen.
The 108 volunteers who completed the first phase of the clinical trial on March 27 have ended centralized medical observation and are in good condition.
The second phase will recruit 500 volunteers and introduce the placebo control group to further evaluate the immunogenicity and safety of the vaccine. As of 5pm on April 13, 273 volunteers had been vaccinated.
An inactivated vaccine candidate developed by the Wuhan Institute of Biological Products under the China National Pharmaceutical Group (Sinopharm) and the Wuhan Institute of Virology under the Chinese Academy of Sciences was approved for clinical trials on April 12, Wu said.
According Sinopharm, the company has allocated 1 billion yuan (US$142 million) for vaccine research and development in two technological approaches.
Besides the approved inactivated vaccine, the company is also working on another inactivated vaccine and a genetic engineering vaccine.
Another inactivated vaccine developed by Beijing-based Sinovac Research and Development Co was approved on April 13.
Using killed pathogenic microorganisms to enhance the immunogenicity, inactivated vaccines have advantages of mature production process, controllable quality standards and wide protection range, according to Wang Junzhi, an academician with the Chinese Academy of Engineering.
To produce the vaccine, researchers cultivate live viruses on a large scale in P3 laboratories, which have relatively high biosafety standards, Wang said.
Experts have been invited to give whole-process direction in the preclinical animal experiments of the vaccines, including acute toxicity experiments, repeated toxicity experiments and immunogenicity experiments, he said.
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