New gene that lowers cholesterol
Print Edition
Chinese researchers have identified a gene variant that can reduce cholesterol absorption to lower low-density lipoprotein cholesterol (LDL-C), known as 鈥渂ad鈥 cholesterol, high levels of which may cause cardiovascular disease.
The study, led by Song Baoliang of Wuhan University and Ma Yitong of Xinjiang Medical University, was published in the journal Science.
The team identified a rare variant in the LIMA1 gene from a Chinese family of Kazakh ethnicity with inherited low LDL-C and reduced cholesterol absorption.
After experiments on mice, researchers found that LIMA1 was mainly expressed in the small intestine and it began to regulate absorption of cholesterol after interaction with NPC1L1, an essential protein for cholesterol absorption. The mice then displayed reduced cholesterol absorption and were resistant to diet-induced high cholesterol.
Keeping LDL-C within limits in the bloodstream can reduce the risk of heart attack and stroke.
- About Us
- |
- Terms of Use
- |
-
RSS - |
- Privacy Policy
- |
- Contact Us
- |
- Shanghai Call Center: 962288
- |
- Tip-off hotline: 52920043
- 娌狪CP璇侊細娌狪CP澶05050403鍙-1
- |
- 浜掕仈缃戞柊闂讳俊鎭湇鍔¤鍙瘉锛31120180004
- |
- 缃戠粶瑙嗗惉璁稿彲璇侊細0909346
- |
- 骞挎挱鐢佃鑺傜洰鍒朵綔璁稿彲璇侊細娌瓧绗354鍙
- |
- 澧炲肩數淇′笟鍔＄粡钀ヨ鍙瘉锛氭勃B2-20120012
Copyright 漏 1999- Shanghai Daily. All rights reserved.Preferably viewed with Internet Explorer 8 or newer browsers.
