Black Americans' asthma hope
Source: Agencies |
August 2, 2011, Tuesday
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US researchers have discovered a genetic mutation unique to African Americans that could help explain why blacks are so susceptible to asthma.
Prior studies looking for asthma genes have turned up several, but most of the studies have been too small to confirm these genes or to detect genetic changes unique to different races.
The new study, published on Sunday in the journal Nature Genetics, pools research from nine different research groups looking for genes associated with asthma among ethnically diverse North American populations.
It confirmed four genes that had been seen in previous studies and a fifth that shows up only in people of African descent.
"This is the first discovery of a gene where we see a signal in African Americans only," Dan Nicolae of the University of Chicago, a study author and co-chair of a national research consortium called EVE that identified the gene, said.
"Rates of asthma in different ethnic groups are different. African Americans have shown increasing rates. We don't know why. It could be due to changing environmental risk factors," Nicolae said.
But, he said, the new findings suggest genetics also play a significant role.
"Understanding these genetic links is an important first step toward our goal of relieving the increased burden of asthma in this population," said Dr Susan Shurin, acting director of the National Heart, Lung, and Blood Institute, one of the National Institutes of Health, which co-funded the study.
Asthma affects more than 300 million people globally. According to the researchers, US asthma rates in 2001 to 2003 ranged from 7.7 percent among European Americans to 12.5 percent among African Americans.
Carole Ober of the University of Chicago, who co-leads the EVE consortium, said the findings confirm the significance of four genes identified in a large European asthma genetics study called GABRIEL, published last year, offering strong evidence that these genes are important across ethnic groups.
But because the study was so large and ethnically diverse it enabled the researchers to find this new gene variant that exists only in African Americans and Afro Caribbeans.
This new variant, located in a gene called PYHIN1, is part of a family of genes linked with the body's response to viral infections, Ober said. "We were very excited when we realized it doesn't exist in Europe," she said.
The findings now give researchers new areas to explore and may lead to better treatments. "What you see in this paper is only the beginning," Nicolae said.
Prior studies looking for asthma genes have turned up several, but most of the studies have been too small to confirm these genes or to detect genetic changes unique to different races.
The new study, published on Sunday in the journal Nature Genetics, pools research from nine different research groups looking for genes associated with asthma among ethnically diverse North American populations.
It confirmed four genes that had been seen in previous studies and a fifth that shows up only in people of African descent.
"This is the first discovery of a gene where we see a signal in African Americans only," Dan Nicolae of the University of Chicago, a study author and co-chair of a national research consortium called EVE that identified the gene, said.
"Rates of asthma in different ethnic groups are different. African Americans have shown increasing rates. We don't know why. It could be due to changing environmental risk factors," Nicolae said.
But, he said, the new findings suggest genetics also play a significant role.
"Understanding these genetic links is an important first step toward our goal of relieving the increased burden of asthma in this population," said Dr Susan Shurin, acting director of the National Heart, Lung, and Blood Institute, one of the National Institutes of Health, which co-funded the study.
Asthma affects more than 300 million people globally. According to the researchers, US asthma rates in 2001 to 2003 ranged from 7.7 percent among European Americans to 12.5 percent among African Americans.
Carole Ober of the University of Chicago, who co-leads the EVE consortium, said the findings confirm the significance of four genes identified in a large European asthma genetics study called GABRIEL, published last year, offering strong evidence that these genes are important across ethnic groups.
But because the study was so large and ethnically diverse it enabled the researchers to find this new gene variant that exists only in African Americans and Afro Caribbeans.
This new variant, located in a gene called PYHIN1, is part of a family of genes linked with the body's response to viral infections, Ober said. "We were very excited when we realized it doesn't exist in Europe," she said.
The findings now give researchers new areas to explore and may lead to better treatments. "What you see in this paper is only the beginning," Nicolae said.
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