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January 15, 2010

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Male gene evolves far faster, study finds

WOMEN may think of men as primitive, but new research indicates that the Y chromosome - the thing that makes a man male - is evolving far faster than the rest of the human genetic code.

A new study comparing the Y chromosomes from humans and chimpanzees, our nearest living relatives, shows that they are about 30 percent different. That is far greater than the 2 percent difference between the rest of the human genetic code and that of the chimp's, according to a study appearing online on Wednesday in the journal Nature.

These changes occurred in the last 6 million years or so, relatively recently when it comes to evolution.

"The Y chromosome appears to be the most rapidly evolving of the human chromosomes," said study co-author Dr David Page, director of the prestigious Whitehead Institute in Cambridge and a professor of biology at MIT. "It's an almost ongoing churning of gene reconstruction. It's like a house that's constantly being rebuilt."

Before men get too impressed with themselves, lead author Jennifer Hughes offers some words of caution: Just because the Y chromosome, which determines gender, is evolving at a speedy rate it doesn't necessarily mean men themselves are more evolved.

Researchers took the most detailed examination of the Y chromosome, which females do not have, of both humans and chimps and found entire sections dramatically different. There were even entire genes on the human Y chromosome that weren't on the chimp, said Hughes, also of the Whitehead Institute.

The two-year research took twice as long as expected because of the evolutionary changes found, Hughes said.

There is a bit of a proviso to the comparison to other chromosomes.

While all human and chimp chromosomes have been mapped, only two chimp chromosomes have been examined in great detail: Y and chromosome 21. Yet, there's still enough known to make the claim that the Y evolves faster, Hughes and Page said.

Until recently the Y chromosome was considered the unassuming figure of genetics, especially because it had fewer genes than other chromosomes. A few years ago some researchers even suggested that the Y chromosome was shrinking so that in 50,000 years it would just disappear - and so would men.

"The story is not as cut and dried as many would have liked to predict," Hughes said. "It's kind of fun to say that men are going to die out, but the science is proving - now that we've got data - that that's not true at all."

Page agreed. "The Y chromosome has many more tricks up its sleeve than it was given credit for," he said.




 

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