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April 1, 2010

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Mammograms save 2 lives for 1 overtreatment


REGULAR mammographic screening for breast cancer saves the lives of two women for every one who is given unnecessary treatment, scientists said yesterday, in a study that adds to a global row over screening programs.

The British researchers said their work showed the benefits outweigh the harm screening can cause by picking up tumors that would not have presented a problem.

"Unfortunately, we haven't yet got a flawless screening test, and some cases that are picked up wouldn't have needed treatment," said Stephen Duffy of Queen Mary, University of London, who led the study.

"But for every case like this, screening saves two women who would have otherwise died from breast cancer."

Duffy's findings contradict the results of a Nordic study published last week that found no evidence routinely screening women for breast cancer had any effect on death rates.

The findings will also further fan a row that erupted in the United States last November after public health officials on the US Preventive Services Task Force questioned whether annual screening mammograms for women under 40 actually saved lives and suggested raising the screening age to 50.

Cancer doctors and advocacy groups decried the move, saying the changes would mean more women die of breast cancer.

Breast cancer is the most common cancer in women worldwide, accounting for about 16 percent of all female cancers. It kills about 519,000 people globally each year.

Duffy and colleagues conducted two studies into the risk-benefit balance of screening programs. One study predicted the number of women who would have died from breast cancer in Britain if the breast cancer screening program had not been launched in 1988, and another looked at the number of breast cancer deaths among 80,000 women in Sweden, comparing those offered screening with those who were not.

The results, published in the Journal of Medical Screening, showed a "substantial and significant reduction in breast cancer deaths" from mammographic breast cancer screening with "between 2 and 2.5 lives saved" for every overdiagnosed case.

Lesley Walker, from Cancer Research UK, said the study showed screening saves lives.





 

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