Missing DNA makes humans unique
Source: Agencies |
March 11, 2011, Friday
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MISSING chunks of DNA responsible for turning genes on and off help explain some key differences between chimpanzees and humans - including why humans have big brains and why the human penis is not covered with prickly spines, according to US researchers.
The study, published in the journal Nature, reinforces the notion that genes controlling the activity of other genes play a big role in what makes humans so different.
To study this, David Kingsley of the Howard Hughes Medical Institute and Stanford University School of Medicine in California and colleagues compared the genetic code of humans to chimpanzees - the closest relative to humans - and other mammals.
They found 510 gene segments that are present in chimps and other mammals, but are missing in humans. Nearly all of these were regulatory genes - genetic switches that turn up or down the volume of nearby genes.
Then the team did a computer analysis to identify deleted DNA segments that were clustered around particular genes.
The team narrowed the pool until they found a few dozen genes they thought were involved in the evolution of particular human traits.
They found one of sections of DNA deleted in the human genome was responsible for producing sensory whiskers, such as those in mice, and prickly spines, like those found on the penises of many mammals.
"People are always surprised to hear that the penis of many organisms are covered with these spines," Kingsley said. Penile spines, or barbs, are typically present in species that mate quickly, such as male chimpanzees who must compete to fertilize one or two receptive females, he explained.
These spines - made from keratin, the protein found in fingernails - often lie over sensory receptors, and some experiments suggest removing them makes copulation last longer.
For humans, losing these penile spines might have prolonged intercourse and helped make monogamous relationships a more attractive option, the team said. Even more interesting is that another of the DNA deletions was located near a gene that kept brain cell growth in check. The deletion of this DNA may have contributed to the development of larger brains in humans.
Both of these traits may be related to meeting the reproductive needs of humans, which give birth to babies with large brains, requiring parents to mate in pairs - at least long enough to care for their big-headed offspring.
The study, published in the journal Nature, reinforces the notion that genes controlling the activity of other genes play a big role in what makes humans so different.
To study this, David Kingsley of the Howard Hughes Medical Institute and Stanford University School of Medicine in California and colleagues compared the genetic code of humans to chimpanzees - the closest relative to humans - and other mammals.
They found 510 gene segments that are present in chimps and other mammals, but are missing in humans. Nearly all of these were regulatory genes - genetic switches that turn up or down the volume of nearby genes.
Then the team did a computer analysis to identify deleted DNA segments that were clustered around particular genes.
The team narrowed the pool until they found a few dozen genes they thought were involved in the evolution of particular human traits.
They found one of sections of DNA deleted in the human genome was responsible for producing sensory whiskers, such as those in mice, and prickly spines, like those found on the penises of many mammals.
"People are always surprised to hear that the penis of many organisms are covered with these spines," Kingsley said. Penile spines, or barbs, are typically present in species that mate quickly, such as male chimpanzees who must compete to fertilize one or two receptive females, he explained.
These spines - made from keratin, the protein found in fingernails - often lie over sensory receptors, and some experiments suggest removing them makes copulation last longer.
For humans, losing these penile spines might have prolonged intercourse and helped make monogamous relationships a more attractive option, the team said. Even more interesting is that another of the DNA deletions was located near a gene that kept brain cell growth in check. The deletion of this DNA may have contributed to the development of larger brains in humans.
Both of these traits may be related to meeting the reproductive needs of humans, which give birth to babies with large brains, requiring parents to mate in pairs - at least long enough to care for their big-headed offspring.
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