New gene test could bare breast cancer risk
Source: Agencies |
August 31, 2011, Wednesday
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Print Edition
Print Edition
Screening for mutations in a gene known as CHEK2 may help determine a woman's odds of breast cancer if the disease runs in her family, according to a Polish study.
Cezary Cybulski of the Pomeranian Medical University in Szczecin and his team said that a woman who carries a CHEK2 mutation would have a 34 percent risk of developing breast cancer if her mother or sister had the disease.
American experts, however, cautioned that Polish women might be different than those in the United States and said that the test isn't quite ready for widespread use yet.
Women with a family history of breast or ovarian cancer are already encouraged to get screened for mutations in the BRCA 1 and 2 genes that warn of a heightened tumor risk.
"CHEK2 mutation screening detects a clinically meaningful risk of breast cancer and should be considered in all women with a family history of breast cancer," Cybulski wrote in the Journal of Clinical Oncology.
Polish researchers tested the genes of nearly 7,500 women with breast cancer who didn't have BRCA 1 mutations and found that 3 percent had a certain type of mutation in the CHEK2 gene. But fewer than one percent without breast cancer harbored such mutations. Although CHEK2 has been tied to cancer before, it wasn't clear what role cancer in the family played.
Cezary Cybulski of the Pomeranian Medical University in Szczecin and his team said that a woman who carries a CHEK2 mutation would have a 34 percent risk of developing breast cancer if her mother or sister had the disease.
American experts, however, cautioned that Polish women might be different than those in the United States and said that the test isn't quite ready for widespread use yet.
Women with a family history of breast or ovarian cancer are already encouraged to get screened for mutations in the BRCA 1 and 2 genes that warn of a heightened tumor risk.
"CHEK2 mutation screening detects a clinically meaningful risk of breast cancer and should be considered in all women with a family history of breast cancer," Cybulski wrote in the Journal of Clinical Oncology.
Polish researchers tested the genes of nearly 7,500 women with breast cancer who didn't have BRCA 1 mutations and found that 3 percent had a certain type of mutation in the CHEK2 gene. But fewer than one percent without breast cancer harbored such mutations. Although CHEK2 has been tied to cancer before, it wasn't clear what role cancer in the family played.
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