New hope for HIV cure in 鈥榚lite controllers鈥
Print Edition
A HANDFUL of people with HIV are able to control the disease without treatment, and now research on these so-called 鈥渆lite controllers鈥 is offering clues in the search for a cure.
For most people with HIV, controlling the virus requires a daily, lifelong regime of anti-retroviral therapy due to the nature of HIV and how it replicates. But in the tiny number of 鈥渆lite controllers,鈥 HIV don鈥檛 seem to behave the same way.
After sequenced billions of cells taken from 64 elite controllers living with the virus without ART, and 41 people on ART, scientists find the location of viral genomes is the vital point.
In elite controllers, HIV was often found in locations of the human genome that researchers call 鈥済ene deserts.鈥
鈥淚n these inactive parts of the human genome, human DNA is never turned on, and thus HIV ... remains in a 鈥榖locked and locked鈥 state,鈥 said Xu Yu, an associate professor of medicine at Harvard Medical School, who led the research.
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