Smart mice may offer clues to treating Alzheimer’s
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SCIENTISTS have genetically modified mice to be super-intelligent and said they are also less anxious, a discovery that might help the search for treatments for disorders such as Alzheimer’s and schizophrenia.
Researchers from Britain and Canada found that altering a single gene to block the phosphodiesterase-4B (PDE4B) enzyme, which is found in many organs including the brain, made mice cleverer and at the same time less fearful.
“Our work using mice has identified phosphodiesterase-4B as a promising target for new treatments,” said Steve Clapcote, a lecturer in pharmacology at Leeds University in England, who led the study.
His team is now working on developing drugs that will specifically inhibit PDE4B. The drugs will be tested first in animals to see whether any of them might be suitable to go forward into clinical trials in humans, he said.
In the experiments, published yesterday in the academic journal Neuropsychopharmacology, the scientists ran a series of behavioral tests on the PDE4B-inhibited mice and found they tended to learn faster, remember events longer and solve complex problems better than normal mice.
The “brainy” mice were better at recognizing a mouse they had seen the previous day, and also quicker at learning the location of a hidden escape platform.
They also appeared to suffer less anxiety, choosing to spend more time in open, brightly lit spaces than normal mice.
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