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April 16, 2013

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Top US court hears case on gene patents

DNA may be the building block of life, but can something taken from it also be the building block of a multimillion-dollar medical monopoly?

The US Supreme Court yesterday grappled with the question of whether human genes can be patented. Its ultimate answer could reshape medical research, the fight against diseases like breast and ovarian cancer and the multi-billion dollar medical and biotechnology business.

"The intellectual framework that comes out of the decision could have a significant impact on other patents - for antibiotics, vaccines, hormones, stem cells and diagnostics on infectious microbes that are found in nature," Robert Cook-Deegan, director for genome ethics, law & policy at Duke University, said.

"This could affect agricultural biotechnology, environmental biotechnology, green-tech, the use of organisms to produce alternative fuels and other applications," he said.

The nine justices' decision will also have a profound effect on US business, with billions of dollars of investment and years of research on the line. The US Patent and Trademark Office has been awarding patents on human genes for almost 30 years.

And Myriad Genetics alone has US$500 million invested in the patents being argued over in this case. Without the ability to recoup that investment, breakthrough scientific discoveries needed to combat all kind of medical maladies wouldn't happen, the company says.

"Countless companies and investors have risked billions of dollars to research and develop scientific advances under the promise of strong patent protection," said Peter D. Meldrum, the president and CEO of Myriad Genetics.

But their opponents argue that allowing companies like Myriad to patent human genes or parts of human genes will slow down or cripple lifesaving medical research like in the battle against breast cancer.

"What that means is that no other researcher or doctor can develop an additional test, therapy or conduct research on these genes," said Karuna Jagger, executive director of Breast Cancer Action.

The Supreme Court has already said that abstract ideas, natural phenomena and laws of nature cannot be given a patent, which gives an inventor the right to prevent others from making, using or selling a novel device, process or application.

Myriad's case involves patents on two genes linked to increased risk of breast and ovarian cancer. Myriad's BRACAnalysis test looks for mutations on the breast cancer predisposition gene, or BRCA. Those mutations are associated with much greater risks of breast and ovarian cancer.

The company sells the only BRCA gene test.





 

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