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December 31, 2020

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UK gives 1st approval for AstraZeneca/Oxford jab

Britain yesterday became the first country in the world to approve the coronavirus vaccine developed by drug maker AstraZeneca and Oxford University, with a mass rollout planned from January 4.

The vaccine can be stored, transported and handled at normal refrigerated conditions, and is therefore cheaper and easier to administer than the Pfizer/BioNTech and Moderna jabs that require ultra-temperature storage.

The UK government said in a statement that it had 鈥渢oday accepted the recommendation from the Medicines and Healthcare products Regulatory Agency to authorise Oxford University/AstraZeneca鈥檚 COVID-19 vaccine for use.鈥

Britain will become the first country to roll out the jab on January 4, Health Secretary Matt Hancock said, amid mounting concerns that another dangerous spike in infections could overwhelm the NHS.

鈥淏rilliant to end 2020 with such a moment of hope,鈥 tweeted Hancock.

The country is struggling with another surge in the virus, with a record 53,135 cases reported on Tuesday. More than 71,000 people testing positive for the disease have died so far, one of the worst tolls in the world.

The government has ordered 100 million doses, with 40 million doses scheduled to be available by the end of March.

The MHRA approved the vaccine after receiving an application on December 23.

On Sunday, AstraZeneca鈥檚 Chief Executive Pascal Soriot said the vaccine provides 鈥100 percent protection鈥 against severe COVID disease requiring hospitalization. He predicted trials would show his firm had achieved a vaccine efficacy equal to Pfizer/BioNTech and Moderna.

Earlier trials had shown varying outcomes in the AstraZeneca shot鈥檚 efficacy.

Initial large-scale trials in which volunteers in the UK and Brazil were given two full doses showed 62 percent effectiveness. For volunteers who received a half-dose first and then a full dose one month later, however, the vaccine was found to have 90 percent efficacy.

The values were averaged to give the 70 percent figure initially reported by the developers.

Despite criticism of the discrepancies in the results and a perceived lack of transparency by AstraZeneca, great hopes have been placed on the shot, originally based on a weakened version of a chimpanzee virus, because of its low cost.

AstraZeneca鈥檚 vaccine also enjoys a logistical advantage over the Pfizer/BioNTech alternative, as it can be stored, transported and handled at normal refrigerated conditions of between 2 and 8 degrees Celsius for at least six months which is far from the minus 70 degrees Celsius needed for Pfizer/BioNTech鈥檚 vaccine.


 

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