UK team discovers cancer gene
Source: Agencies |
January 25, 2011, Tuesday
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BRITISH scientists have discovered a "rogue gene" which helps cancer spread around the body and say blocking it with the right kind of drugs could stop many types of the disease in their tracks.
Researchers from the University of East Anglia said their findings could lead within a decade to the development of new medicines to halt a critical late stage of the disease known as -metastasis, when cancer cells spread to other parts of the body.
The culprit gene, called WWP2, is an enzymic bonding agent found inside cancer cells, the researchers explained in their study, published in the medical journal Oncogene yesterday.
It attacks and breaks down a naturally-occurring protein in the body which can prevent cancer cells from spreading.
In laboratory tests, the UEA team found that by blocking WWP2, levels of the natural inhibitor protein rose and the cancer cells remained dormant.
Surinder Soond, who worked on the study, said it was an "exciting approach to treating cancer and the spread of tumors which holds great potential."
"The challenge now is to identify a potent drug that will get inside cancer cells and destroy the activity of the rogue gene," said Andrew Chantry of UEA's school of biological sciences.
Chantry said that this was "a difficult but not impossible task."
Researchers from the University of East Anglia said their findings could lead within a decade to the development of new medicines to halt a critical late stage of the disease known as -metastasis, when cancer cells spread to other parts of the body.
The culprit gene, called WWP2, is an enzymic bonding agent found inside cancer cells, the researchers explained in their study, published in the medical journal Oncogene yesterday.
It attacks and breaks down a naturally-occurring protein in the body which can prevent cancer cells from spreading.
In laboratory tests, the UEA team found that by blocking WWP2, levels of the natural inhibitor protein rose and the cancer cells remained dormant.
Surinder Soond, who worked on the study, said it was an "exciting approach to treating cancer and the spread of tumors which holds great potential."
"The challenge now is to identify a potent drug that will get inside cancer cells and destroy the activity of the rogue gene," said Andrew Chantry of UEA's school of biological sciences.
Chantry said that this was "a difficult but not impossible task."
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